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Cognitive dysfunction

GABAA receptor a5 (GABRA5)

Mouse studies suggest selective GABRA5 negative allosteric modulators could help treat cognitive dysfunction in Down syndrome. In a transgenic mouse model for Down syndrome, the GABRA5 negative allosteric modulator RO4938581 increased spatial learning, memory and attention compared with vehicle. In these mice, RO4938581 did not induce anxiety-like behaviors or convulsions. Next steps include additional preclinical studies with RO4938581.
Roche has RG1662 in Phase I testing to treat Alzheimer's disease (AD) and cognitive dysfunction associated with Down syndrome.

SciBX 6(9); doi:10.1038/scibx.2013.221
Published online March 7, 2013

Patented; unavailable for licensing

Martínez-Cué, C. et al. J. Neurosci.; published online Feb. 27, 2013;
Contact: Maria-Clemencia Hernández, Roche, Basel, Switzerland