This week in therapeutics

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Target/marker/pathway

Summary

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Publication and contact information

Infectious diseases

Gram-positive bacterial infection; Staphylococcus

Lipoteichoic acid synthase (LtaS)

A study in vitro and in mice suggests inhibiting LtaS could help treat infections of Staphylococcus aureus and other Gram-positive bacteria. A high throughput screen identified a compound that blocked LtaS in vitro and inhibited the growth and altered the cell wall morphology of S. aureus, methicillin-resistant S. aureus and other Gram-positive bacteria at single-digit micromolar concentrations. In a mouse model for Staphylococcus sepsis, the compound increased survival compared with vehicle. Next steps include improving the in vivo stability and efficacy of inhibitors in animal models.

SciBX 6(9); doi:10.1038/scibx.2013.218
Published online March 7, 2013

Patent application filed; available for licensing

Richter, S.G. et al. Proc. Natl. Acad. Sci. USA; published online Feb. 11, 2013;
doi:10.1073/pnas.1217337110
Contact: Dominique Missiakas,
The University of Chicago, Chicago, Ill.
e-mail:

dmissiak@bsd.uchicago.edu