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Solid tumors

Phosphatidylinositol glycan anchor biosynthesis class N (PIGN);
mex-3 homolog C
(MEX3C); zinc finger protein 516 (ZNF516)

Patient sample and cell culture studies suggest nucleoside supplementation could help treat solid tumors. In 26 colorectal tumor samples and 20 cell lines showing chromosomal instability, PIGN, MEX3C and ZNF516 were identified as suppressors of chromosomal instability and were frequently deleted in tumors. In a colorectal cancer cell line lacking PIGN, MEX3C or ZNF516, nucleoside supplementation decreased markers of chromosome instability compared with no treatment. Next steps include determining the role of PIGN, MEX3C and ZNF516 in normal cells.

SciBX 6(9); doi:10.1038/scibx.2013.215
Published online March 7, 2013

Unpatented; licensing details available from Cancer Research Technology Ltd.

Burrell, R.A. et al. Nature; published online Feb. 27, 2013;
Contact: Charles Swanton, Cancer Research UK London Research Institute, London, U.K.