This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Cancer

Phosphatase and tensin homolog pseudogene 1
(PTENP1; PTENpg1); PTEN (MMAC1; TEP1)

Cell culture studies suggest inhibiting PTENpg1-encoded antisense RNA could help treat cancer. PTENpg1 is a nonfunctional homolog of PTEN that positively regulates PTEN translation by binding and depleting microRNAs. In a panel of cell lines, a PTENpg1 antisense RNA was detected and its expression inversely correlated with PTEN expression. In cultured cells treated with the generic chemotherapeutic doxorubicin, small interfering RNA against PTENpg1 antisense RNA increased cell death compared with control siRNA. Next steps include inhibiting the PTENpg1 antisense RNA in disease models.

SciBX 6(9); doi:10.1038/scibx.2013.214
Published online March 7, 2013

Patent application filed; available for licensing

Johnsson, P. et al. Nat. Struct. Mol. Biol.; published online Feb. 24, 2013;
doi:10.1038/nsmb.2516
Contact: Kevin V. Morris, The Scripps Research Institute, La Jolla, Calif.
e-mail:

kmorris@scripps.edu
Contact: Dan Grandér, Karolinska Institute, Stockholm, Sweden
e-mail:

dan.grander@ki.se