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Alzheimer's disease (AD)

Prion protein (PRNP; PrP; CD230)

In vitro and mouse studies suggest the soluble N1 fragment of PrP could help treat AD. In vitro, both the N1 fragment and full-length PrP bound synthetic b-amyloid (Ab) oligomers and inhibited fibril formation. In a mouse model for Ab toxicity, intracerebroventricular microinfusion of Ab oligomers impaired cognition and behavior, whereas microinfusion of a mixture of Ab oligomers and N1 did not. Next steps include designing N1-derived peptides with improved CNS penetration.

SciBX 6(8); doi:10.1038/scibx.2013.199
Published online Feb. 28, 2013

Findings unpatented; licensing status not applicable

Fluharty, B.R. et al. J. Biol. Chem.; published online Jan. 28, 2013;
Contact: Emiliano Biasini, Boston University School of Medicine, Boston, Mass.