Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Asthma

Forkhead box P3 (FOXP3)

Mice studies suggest modified FOXP3 mRNA could help prevent or treat allergy-induced asthma. In mice, intratracheal delivery of Foxp3 mRNA modified with 2-thiouridine and 5-methylcytidine led to greater Foxp3 expression in immune cells in the lung and lower allergen-induced lung inflammation than intratracheal delivery of saline. Next steps include optimizing mRNA modifications, formulations and delivery approaches, including development of a powder for inhalation.

SciBX 6(8); doi:10.1038/scibx.2013.198
Published online Feb. 28, 2013

Unpatented; licensing status not applicable

Mays, L.E. et al. J. Clin. Invest.; published online Feb. 8, 2013;
doi:10.1172/JCI65351
Contact: Michael S.D. Kormann, University of Tuebingen, Tuebingen, Germany
e-mail:
kormann.michael@gmail.com