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Publication and contact information

Infectious disease

Influenza virus

Influenza A virus hemagglutinin (HA)

Mouse studies suggest a liposome formulation of a sialic acid-based sugar could help prevent or treat influenza infection. The sugar sialylneolacto-N-tetraose c blocks the interaction of HA with host cells. In mice infected with influenza A virus, liposome-mediated delivery of the sugar during viral challenge led to greater survival than delivery of control liposomes. Next steps include optimizing the sugar chemistry and liposome formulation.

SciBX 6(8); doi:10.1038/scibx.2013.197
Published online Feb. 28, 2013

Patent and licensing status undisclosed

Hendricks, G.L. et al. J. Biol. Chem.; published online Jan. 28, 2013;
Contact: Jennifer P. Wang, University of Massachusetts Medical School, Worcester, Mass.