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MicroRNA-198 (miR-198); follistatin-like 1 (FSTL1)

Patient sample and cell culture studies suggest inhibiting miR-198 could help treat chronic diabetic wounds. miR-198 is encoded within an exon of FSTL1. In tissue samples from nonhealing ulcers on patients with diabetes, miR-198 expression was greater and FSTL1 expression was lower than that seen in tissue samples from wounded healthy skin. In cell culture, small interfering RNA knockdown of FSTL1 or overexpression of miR-198 decreased wound healing compared with control treatment. Next steps include conducting additional studies to understand the regulatory mechanisms controlling the switch between FSTL1 and miR-198 expression and developing antagomirs against miR-198.

SciBX 6(8); doi:10.1038/scibx.2013.194
Published online Feb. 28, 2013

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Sundaram, G.M. et al. Nature; published online Feb. 10, 2013;
Contact: Prabha Sampath, Institute of Medical Biology, Agency for Science, Technology and Research (A*STAR), Singapore