This week in therapeutics




Licensing status

Publication and contact information

Renal disease

Renal disease

WAP four-disulfide core domain 2 (WFDC2; HE4)

Studies in patient tissue and in mice suggest antagonizing HE4 could help treat renal fibrosis. In patients with renal fibrosis, HE4 expression was greater in the kidneys and levels of the protein were higher in sera than those in healthy controls. In three mouse models of renal disease, an anti-HE4 antibody decreased fibrosis compared with a control antibody. Next steps could include developing a human mAb targeting HE4.

SciBX 6(7); doi:10.1038/scibx.2013.172
Published online Feb. 21, 2013

Patent and licensing status unavailable

LeBleu, V.S. et al. Nat. Med.;
published online Jan. 27, 2013;
Contact: Raghu Kalluri, The University of Texas MD Anderson Cancer Center, Houston, Texas