This week in therapeutics

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Neurology

Epilepsy

Prostaglandin E2 receptor EP2 subtype (prostanoid EP2 receptor; PTGER2)

Mouse studies suggest PTGER2 antagonism could help treat status epilepticus, which is characterized by persistent seizures. In a mouse model of pilocarpine-induced status epilepticus, a blood brain barrier-penetrant antagonist of PTGER2 decreased mortality, seizure-induced upregulation of proinflammatory cytokines and hippocampal neurodegeneration compared with vehicle control. Ongoing studies include developing an optimized compound for use in patients who experience more than one hour of status epilepticus.

SciBX 6(7); doi:10.1038/scibx.2013.169
Published online Feb. 21, 2013

Patent application filed; available for licensing

Jiang, J. et al. Proc. Natl. Acad. Sci. USA; published online Feb. 11, 2013;
doi:10.1073/pnas.1218498110
Contact: Jianxiong Jiang, Emory University School of Medicine, Atlanta, Ga.
e-mail:
jjiang3@emory.edu