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Breast cancer

MicroRNA-374a (miR-374a)

Patient sample and mouse studies suggest inhibiting miR-374a could help prevent or treat breast cancer metastasis. In a mouse xenograft model for breast cancer, cells that overexpressed miR-374a caused greater metastasis than cells that expressed normal levels of miR-374a. In cells that expressed normal levels of miR-374a, antagomir-mediated knockdown of miR-374a expression led to less metastasis than no knockdown. Primary tumor samples from breast cancer patients with disease metastasis showed higher miR-374a expression than samples from patients without metastases. Next steps include optimizing the miR-374a antagomir.

SciBX 6(6); doi:10.1038/scibx.2013.132
Published online Feb. 14, 2013

Patent application filed; available for licensing

Cai, J. et al. J. Clin. Invest.; published online Jan. 16, 2013;
Contact: Mengfeng Li, Sun Yat-Sen University, Guangzhou, China