This week in therapeutics




Licensing status

Publication and
contact information


Autoimmune disease; diabetes

Not applicable

Mouse studies suggest enteric microbiota from males could help protect females from type 1 diabetes. In a mouse model of nonobese type 1 diabetes, oral transfer of enteric microbiota from adult male mice to young female mice led to testosterone-dependent decreases in the markers and incidence of type 1 diabetes compared with oral transfer of enteric microbiota from adult female mice or no transfer. Next steps include determining how commensal bacterial consortia regulate testosterone levels and how alterations in testosterone levels attenuate autoimmunity.

SciBX 6(5); doi:10.1038/scibx.2013.121
Published online Feb. 7, 2013

Unpatented; available for partnering from The Hospital for Sick Children
Contact: Arlene Yee, The Hospital for Sick Children, Toronto, Ontario, Canada
phone: 416-813-8858

Markle, J.G.M. et al. Science; published online Jan. 17, 2013;
Contact: Jayne S. Danska, The Hospital for Sick Children Research Institute, Toronto, Ontario, Canada