This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and
contact information

Infectious disease

HBV; HDV

Solute carrier family 10 sodium/bile acid cotransporter family member 1 (SLC10A1)

In vitro and cell culture studies suggest antagonizing SLC10A1 on host cells could help prevent HBV and HDV infection. In vitro mass spectrometry analysis and interaction studies showed that SLC10A1 bound to the envelope proteins of HBV and HDV. In cultured hepatocytes, small interfering RNA-mediated knockdown of SLC10A1 decreased HBV and HDV infection compared with no knockdown. In an immortalized hepatocyte cell line that normally cannot be infected with HBV or HDV, expression of SLC10A1 permitted viral infection. Next steps could include using SLC10A-expressing cell lines to screen for anti-HBV or anti-HDV prophylactics.

SciBX 6(5); doi:10.1038/scibx.2013.118
Published online Feb. 7, 2013

Patent and licensing status unavailable

Yan, H. et al. eLife; published online Nov. 13, 2012;
doi:10.7554/eLife.00049
Contact: Wenhui Li, National Institute of Biological Sciences, Beijing, China
e-mail:
liwenhui@nibs.ac.cn