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Colorectal cancer; colitis

Caspase recruitment domain family member 15 (CARD15; NOD2)

Mouse studies suggest intestinal microbiota from organisms with functional NOD2 could help protect against colitis and colitis-associated colorectal cancer. Wild-type mice cohoused with Nod2-deficient mice showed greater susceptibility to chemically induced colitis and colitis-associated colorectal cancer than wild-type mice that were not housed with Nod2-deficient mice. In a mouse model of chemically induced colitis, Nod2-deficient animals that received a fecal transplant from wild-type animals showed decreased disease histopathology compared with those that received a fecal transplant from Nod2-deficient animals. Next steps include screening for probiotic bacterial strains that could reduce disease susceptibility and elucidating the mechanisms through which Nod2 deficiency disrupts the gut microbiota.

SciBX 6(4); doi:10.1038/scibx.2013.95
Published online Jan. 31, 2013

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Couturier-Maillard, A. et al. J. Clin. Invest.; published online Jan. 2, 2013;
Contact: Mathias Chamaillard, Pasteur Institute in Lille, Lille, France