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Hypoxia-inducible factor prolyl hydroxylase (HIF-PH; EGLN); hypoxia-inducible factor 1a (HIF1A; HIF1a)

Human and rabbit studies suggest compounds that inhibit HIF-PH could prevent neurogenesis deficits in preterm infants. Postmortem brain tissue samples from preterm infants had lower glutamatergic neurogenesis than tissue samples from fetuses. In rabbits, preterm pups showed decreased markers of neurogenesis, hypoxia and angiogenesis compared with full-term pups. In preterm rabbit pups, the HIF-PH inhibitor dimethyloxallyl glycine rescued neurogenesis deficits, whereas vehicle did not. Next steps could include testing additional compounds that inhibit HIF-PH or activate HIF1a in animal models of premature birth.
Dimethyloxallyl glycine is a research reagent.

SciBX 6(4); doi:10.1038/scibx.2013.94
Published online Jan. 31, 2013

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Malik, S. et al. J. Neurosci.; published online Jan. 9, 2013;
Contact: Praveen Ballabh, Westchester Medical Center, Valhalla, N.Y.