Thursday, January 31, 2013
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Free fatty acid receptor 1 (FFAR1;
In vitro and mouse studies identified an alkyne series of
FFAR1 agonists that could help treat type 2
diabetes. In healthy mice, an alkyne-based FFAR1 agonist with polar
substituents on the terminal phenyl ring was orally bioavailable and
increased glucose tolerance at least as much as the marketed type 2 diabetes
Next steps include testing the compounds in rodent models of diabetes.
Life Sciences Pvt. Ltd. has FFAR1 agonists including CNX-011-67
in preclinical testing to treat diabetes.
Pharmaceutical Co. Ltd.'s FFAR1 agonist, TAK-875,
is in Phase III testing for the indication.
& Co. Inc. and Ono
Pharmaceutical Co. Ltd. market the dipeptidyl
inhibitor Glactiv sitagliptin to treat diabetes.
SciBX 6(4); doi:10.1038/scibx.2013.87
Published online Jan. 31, 2013
Patent application filed
covering compounds; available for licensing
Christiansen, E. et al.
J. Med. Chem.; published online Jan. 8, 2013;
Contact: Trond Ulven, University of Southern Denmark,
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