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Alzheimer's disease (AD)

NLR family pyrin domain containing 3 (NLRP3; NALP3); caspase-1 (CASP1)

Human tissue, cell culture and mouse studies suggest antagonizing NALP3 or CASP1 could help prevent AD. In postmortem patient brain tissue samples, CASP1 activity was higher than that in tissue from healthy controls. In a transgenic mouse model of AD, deletion of Nalp3 or Casp1 increased learning and memory and decreased both neuroinflammation and accumulation of b-amyloid (Ab) aggregates compared with no deletion. Next steps include identifying compounds that inhibit Nalp3 or Casp1 and testing them in mouse models of AD.

SciBX 6(3); doi:10.1038/scibx.2013.62
Published online Jan. 24, 2013

Unpatented; licensing status not applicable

Heneka, M.T. et al. Nature; published online Dec. 19, 2012;
Contact: Eicke Latz, University of Bonn, Bonn, Germany
Contact: Michael T. Heneka, same affiliation as above