This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Inflammation

Asthma

Lactadherin (MFGE8; HMFG)

Mouse studies suggest increasing MFGE8 levels could help treat asthma. In two mouse models of allergen-induced asthma, Mfge8 knockout increased asthma-associated airway hyperresponsiveness compared with no knockout. Tracheal rings from Mfge8 knockout mice showed greater sensitivity to cytokines that cause airway hyperresponsiveness than rings from wild-type mice. In tracheal rings from humans and Mfge8 knockout mice, recombinant MFGE8 prevented the cytokine-induced muscle contractions. Next steps include optimizing the recombinant protein and testing it in animal models.

SciBX 6(3); doi:10.1038/scibx.2013.59
Published online Jan. 24, 2013

Findings unpatented; available for licensing

Kudo, M. et al. Proc. Natl. Acad. Sci. USA; published online
Dec. 26, 2012;
doi:10.1073/pnas.1216673110
Contact: Kamran Atabai, University of California,
San Francisco, Calif.
e-mail:

kamran.atabai@ucsf.edu