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Infectious disease


Calcitonin receptor-like (CALCRL; CRLR)

Rat studies suggest decreasing CRLR expression in the intestines could help treat Clostridium difficile infection. In rats, double-stranded RNA-mediated inhibition of CRLR expression in the ileum prior to injection of C. difficile toxin A
decreased both intestinal secretions and toxin-induced inflammation compared with no inhibition. Next steps could include testing the effects of decreasing CRLR in additional models of C. difficile infection.

SciBX 6(3); doi:10.1038/scibx.2013.57
Published online Jan. 24, 2013

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Bhargava, A. et al. Proc. Natl. Acad. Sci. USA; published online Dec. 24, 2012;
Contact: Susan E. Leeman, Boston University School of Medicine, Boston, Mass.