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Parkinson's disease (PD)

Dopamine D2 receptor

In vitro and mouse studies suggest dopamine D2 receptor agonists could help treat neuroinflammation in diseases such as PD. Mice with dopamine D2 receptor knockout showed greater astrocyte activation and expression of inflammatory factors, lower levels of neuroprotective crystallin aB (CRYAB; HSPB5) and more severe toxin-induced neuroinflammation than wild-type mice. In a mouse model of PD, the dopamine D2 receptor agonist quinpirole decreased neuroinflammation and loss of dopaminergic neurons compared with saline. Next steps include developing astrocyte-specific dopamine D2 receptor agonists.
Quinpirole is a research compound.
At least nine companies have dopamine receptor D2 agonists in development stages ranging from preclinical to marketed for neurological indications.

SciBX 6(2); doi:10.1038/scibx.2013.39
Published online Jan. 17, 2013

Unpatented; licensing status not applicable

Shao, W. et al. Nature; published online
Dec. 16, 2012;
Contact: Jia-wei Zhou, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China