Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Bacterial infection

Undecaprenyl diphosphate synthase (uppS)

In vitro and mouse studies identified inhibitors of uppS that could help treat bacterial infection. Crystallographic and in vitro studies identified a lead compound that inhibited uppS at 100 nM and inhibited Staphylococcus aureus growth at concentrations below 1 mg/mL. In mice infected with S. aureus, a 10 mg/kg injection of the lead compound increased survival compared with vehicle injection. Next steps include synthesizing analogs and solving additional crystal structures of the compounds.

SciBX 6(2); doi:10.1038/scibx.2013.35
Published online Jan. 17, 2013

Patent applications filed; available for licensing

Zhu, W. et al. Proc. Natl. Acad. Sci. USA; published online Dec. 17, 2012;
doi:10.1073/pnas.1219899110
Contact: Eric Oldfield, University of Illinois at Urbana-Champaign, Urbana, Ill.
e-mail:

eo@chad.scs.uiuc.edu
Contact: Yonghui Zhang, same affiliation as above
e-mail:

yhzhang@illinois.edu
Contact: J. Andrew McCammon, University of California, San Diego, La Jolla, Calif.
e-mail:

jmccammon@ucsd.edu