This week in therapeutics

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Neurology

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Mouse studies suggest lithium could help treat Down syndrome. In a mouse model of Down syndrome, chronic treatment with the generic mood stabilizer lithium restored hippocampal neurogenesis to levels that were comparable to those in wild-type controls and promoted proliferation of neural precursor cells. In the lithium-treated mice, compared with saline-treated mice, restoration of neurogenesis increased performance on behavioral and memory tests. Next steps include clinical testing of lithium.

SciBX 6(1); doi:10.1038/scibx.2013.21
Published online Jan. 10, 2013

Unpatented; licensing status not applicable

Contestabile, A. et al. J. Clin. Invest.; published online Dec. 3, 2012;
doi:10.1172/JCI64650
Contact: Laura Gasparini, Italian Institute of Technology, Genoa, Italy
e-mail:
laura.gasparini@iit.it