This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Musculoskeletal disease

Osteoporosis

MicroRNA-214 (miR-214)

In vitro and mouse studies suggest inhibiting miR-214 could help treat osteoporosis. In mouse preosteoblast cells, an anti-miR-214 antagomir increased mineral deposits, whereas a miR-214 mimic decreased deposits. In a mouse model of ovariectomy-induced osteoporosis, osteoblast-specific antagomir-214 increased bone mineral density, bone-to-tissue volume ratios and expression of activating transcription factor 4 (Atf4), which is required for osteoblast function, compared with an antagomir control or vehicle. Next steps include identifying a small molecule inhibitor of miR-214 activity.

SciBX 6(1); doi:10.1038/scibx.2013.18
Published online Jan. 10, 2013

Patent and licensing status unavailable

Wang, X. et al. Nat. Med.; published online Dec. 9, 2012;
doi:10.1038/nm.3026
Contact: Yingxian Li, China Astronaut Research and Training Center, Beijing, China
e-mail:
yingxianli@yahoo.cn

Contact: Ge Zhang, Hong Kong Baptist University, Hong Kong, China
e-mail:
zhangge@hkbu.edu.hk