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Infectious disease

Infectious disease

Protozoan signal peptide peptidase (SPP)

Cell culture studies suggest inhibiting protozoan SPP could help treat parasitic infections. In vitro, a small molecule protozoan SPP inhibitor blocked growth of three different parasites with nanomolar IC50 values without inhibiting host cell growth. Next steps include identifying additional SPP inhibitors in collaboration with the Novartis Institute for Tropical Diseases and evaluating the compounds in mouse models.

SciBX 6(1); doi:10.1038/scibx.2013.14
Published online Jan. 10, 2013

Unpatented; licensing status not applicable

Harbut, M.B. et al. Proc. Natl. Acad. Sci. USA; published online Dec. 11, 2012;
Contact: Doron C. Greenbaum, University of Pennsylvania, Philadelphia, Pa.