This week in therapeutics




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Alzheimer's disease (AD)

Amyloid precursor protein (APP); b-amyloid (Ab)

Cell culture and mouse studies suggest hydroxypropyl-b-cyclodextran could help treat AD. In cultured cells overexpressing mutant human APP, hydroxypropyl-b-cyclodextran decreased membrane cholesterol and Ab levels compared with vehicle. In a mouse model of AD, the compound decreased Ab plaque load and increased learning and memory compared with vehicle. Next steps include modifying the structure of hydroxypropyl-b-cyclodextran to enable tracking of the molecule in the brain and to increase its penetration across the blood brain barrier.

SciBX 5(49); doi:10.1038/scibx.2012.1289
Published online Dec. 20, 2012

Patent application filed; available for licensing

Yao, J. et al. J. Exp. Med.; published online Dec. 3, 2012;
Contact: M. Flint Beal, Weill Cornell Medical College, New York, N.Y.
Contact: Jiaqi Yao, same affiliation as above