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Mouse studies identified a series of bile acid trioxanes that could help treat malaria. In a mouse model of malaria infection, bile acid-based trioxanes that had shorter side-chain lengths and increased polarity showed greater potency against the Plasmodium yoelii parasite than those that had longer side chains and decreased polarity. In the mouse model, the most potent trioxanes provided 100% protection against infection when given at 24 mg/kg a day for 4 days. Next steps could include testing the compounds in additional models of malaria infection.

SciBX 5(49); doi:10.1038/scibx.2012.1286
Published online Dec. 20, 2012

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Singh, C. et al. J. Med. Chem.; published online Nov. 19, 2012;
Contact: Chandan Singh, Council of Scientific and Industrial Research, Central Drug Research Institute, Lucknow, India