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Endocrine/metabolic disease

Diabetes; obesity

G protein-coupled receptor family C group 5 member B (GPRC5B)

Mouse studies suggest inhibiting GPRC5B could help treat obesity and type 2 diabetes. In mice fed a high-fat diet, Gprc5b knockout led to faster glucose removal, lower circulating levels of insulin and glucose and 18% lower body weight than wild-type Gprc5b expression. Next steps could include identifying a GPRC5B inhibitor.

SciBX 5(49); doi:10.1038/scibx.2012.1283
Published online Dec. 20, 2012

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Kim, Y.-J. et al. Sci. Signal.; published online Nov. 20, 2012;
Contact: Yoshio Hirabayashi, RIKEN Brain Science Institute, Saitama, Japan