This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact ­information

Cancer

Renal cell carcinoma (RCC)

Sialidase 3
(NEU3; SIAL3)

Studies in cell culture suggest antagonizing NEU3 could help treat RCC. In cultured RCC cells, small hairpin RNA knockdown of NEU3 decreased signaling through oncogenic pathways, expression of tumor-associated markers and tumor invasiveness compared with no knockdown. Next steps could include identifying NEU3 inhibitors and testing them in cultured RCC cells.

SciBX 5(49); doi:10.1038/scibx.2012.1279
Published online Dec. 20, 2012

Patent and licensing status unavailable

Tringali, C. et al. J. Biol. Chem.; published online Nov. 8, 2012;
doi:10.1074/jbc.M112.407718
Contact: Bruno Venerando, University of Milan, Milan, Italy
e-mail:

bruno.venerando@unimi.it