This week in therapeutics

Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact ­information

Cancer

Acute myelogenous leukemia (AML)

Unknown

Cell culture and mouse studies suggest the generic malaria drug mefloquine could help treat AML. In cultured AML cell lines, mefloquine inhibited cell growth at low micromolar concentrations and disrupted lysosome integrity. In a mouse model of AML, mefloquine decreased tumor volume compared with vehicle control. Next steps include identifying and testing mefloquine analogs that more potently disrupt lysosomes.

SciBX 5(49); doi:10.1038/scibx.2012.1278
Published online Dec. 20, 2012

Unpatented; licensing status not applicable

Sukhai, M.A. et al. J. Clin. Invest.; published online Dec. 3, 2012;
doi:10.1172/JCI64180
Contact: Aaron D. Schimmer, University Health Network, Toronto, Ontario, Canada
e-mail:

aaron.schimmer@utoronto.ca