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Autoimmune disease

Multiple sclerosis (MS)

4-1BB ligand
(4-1BBL; TNFSF9; CD137L)

Mouse studies suggest inhibiting CD137L signaling could help treat MS. In a mouse model of experimental autoimmune encephalomyelitis (EAE), Cd137l knockout decreased leukocyte cytokine secretion, infiltration in the spinal cord and disease severity compared with no knockout. Next steps include evaluating whether an anti-CD137L mAb or a soluble tumor necrosis factor receptor superfamily member 9 (TNFRSF9; 4-1BB; CD137) could help treat EAE.

SciBX 5(49); doi:10.1038/scibx.2012.1277
Published online Dec. 20, 2012

Unpatented; available for licensing

Martínez Gómez, J.M. et al.
J. Neurosci.
; published online
Dec. 12, 2012;
Contact: Herbert Schwarz, National University of Singapore, Singapore