Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Alzheimer's disease (AD)

Arrestin b2 (ARRB2)

In vitro and mouse studies suggest antagonizing ARRB2 could help treat AD. In vitro, ARRB2 coimmunoprecipitated with g-secretase, a proteolytic complex that generates b-amyloid (Ab). In cell culture, overexpression of ARRB2 increased production of Ab and small interfering RNA knockdown of ARRB2 decreased Ab levels compared with what was seen using vector controls. In a mouse model of AD, Arrb2 knockout mice had lower levels of Ab than wild-type controls. Next steps include identifying pharmacological modulators of G protein-coupled receptor 3 (GPR3), a receptor that appears to work upstream of ARRB2 and previously has been implicated in Ab production.

SciBX 5(48); doi:10.1038/scibx.2012.1261
Published online Dec. 13, 2012

Patent pending; unavailable for licensing

Thathiah, A. et al. Nat Med.; published online Dec. 2, 2012;
doi:10.1038/nm.3023
Contact: Bart De Strooper, Catholic University Leuven, Leuven, Belgium
e-mail:
bart.destrooper@cme.vib-kuleuven.be

Contact: Amantha Thathiah, same affiliation as above
e-mail:
amantha.thathiah@cme.vib.kuleuven.be