Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Diabetes; obesity

Not applicable

A clinical study suggests gastric bypass and gastric banding lead to equivalent and weight loss-dependent improvements in insulin sensitivity and b cell function. Previous studies have suggested gastric bypass may cause weight loss-independent effects that normalize glucose homeostasis in patients with obesity. In 20 obese, nondiabetic patients who received either treatment, both groups showed comparable improvements in insulin sensitivity and b cell function that were directly correlated with weight loss. Next steps could include additional studies in patients with diabetes.

SciBX 5(48); doi:10.1038/scibx.2012.1256
Published online Dec. 13, 2012

Patent and licensing status not applicable

Bradley, D. et al. J. Clin. Invest.; published online Nov. 26, 2012;
doi:10.1172/JCI64895
Contact: Samuel Klein, Washington University in St. Louis School of Medicine, St. Louis, Mo.
e-mail:
sklein@dom.wustl.edu