Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Neurology

Neurology

Tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest TIMP3 could help treat traumatic brain injury (TBI). In a mouse model of TBI, i.v. delivery of recombinant TIMP3 increased vascular stability and blood brain barrier integrity compared with delivery of vehicle. Ongoing work includes determining the therapeutic dose range, therapeutic window, toxicities and exact mechanisms of action.

SciBX 5(47); doi:10.1038/scibx.2012.1240
Published online Dec. 6, 2012

Unpatented; licensing status not applicable

Menge, T. et al. Sci. Transl. Med.; published online Nov. 21, 2012;
doi:10.1126/scitranslmed.3004660
Contact: Shibani Pati, Blood Systems Research Institute, San Francisco, Calif.
e-mail:

spati@bloodsystems.org