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Gastrointestinal disease



In vitro and mouse studies suggest inhibiting calcineurin could help treat biliary pancreatitis. Biliary pancreatitis is caused by biliary acid reflux that increases Ca2+ in pancreatic cells. In primary mouse pancreatic acinar cells, bile acid-induced Ca2+ upregulation caused calcineurin activation and cell injury. The process was prevented by Ca2+ chelation or calcineurin inhibition. In a mouse model of bile acid-induced pancreatitis, inhibition of calcineurin decreased disease severity compared with no inhibition. Next steps could include testing calcineurin inhibition in additional animal models.
Isotechnika Pharma Inc., 3SBio Inc. and Paladin Labs Inc. have the calcineurin inhibitor Voclera voclosporin in clinical and preclinical testing for indications including lupus, psoriasis and renal transplant rejection.

SciBX 5(47); doi:10.1038/scibx.2012.1235
Published online Dec. 6, 2012

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Muili, K.A. et al. J. Biol. Chem.; published online Nov. 12, 2012;
Contact: Sohail Z. Husain, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pa.