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Parkinson's disease (PD)

Nitric oxide (NO); PTEN induced putative kinase 1 (PINK1)

Cell culture studies suggest restoring NO signaling could help correct mitochondrial dysfunction in neurodegenerative diseases such as mutant PINK1-associated PD. In Pink1 knockout mouse dopaminergic neurons, a bioactive component of ginseng called Re increased NO signaling compared with no treatment and rescued the dysfunction in mitochondrial cytochrome c oxidase activity. Next steps include evaluating the compound in in vivo models of PD and Alzheimer's disease that include a mitochondrial impairment component.

SciBX 5(46); doi:10.1038/scibx.2012.1213
Published online Nov. 29, 2012

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Ewha Womans University

Kim, K.-H. et al. J. Biol. Chem.; published online Nov. 9, 2012;
Contact: Jin H. Son, Ewha Womans University, Seoul, South Korea