Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cancer

Melanoma

Indoleamine 2,3-dioxygenase (INDO; IDO)

Mouse studies suggest Salmonella typhimurium engineered to express IDO small hairpin RNA could help treat melanoma. The S. typhimurium strain VNP20009 was previously shown to be safe but minimally effective in Phase I cancer trials. In a mouse model of melanoma, infection with VNP20009 modified to express Ido shRNA decreased levels of tumor Ido, tumor growth and melanoma lung metastases compared with infection using VNP20009 expressing control shRNA. Next steps include testing this strain in mice with human melanoma cells.

SciBX 5(45); doi:10.1038/scibx.2012.1182
Published online Nov. 15, 2012

Patent application filed by City of Hope; available for licensing

Blache, C.A. et al. Cancer Res.; published online Oct. 22, 2012;
doi:10.1158/0008-5472.CAN-12-0193
Contact: Edwin R. Manuel, City of Hope, Duarte, Calif.
e-mail:

emanuel@coh.org