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Endocrine/metabolic disease


Serotonin; tryptophan hydroxylase 1 (TPH1; TPH)

Mouse studies suggest inhibiting synthesis of gut-derived serotonin through TPH1 could help treat type 2 diabetes. In mice, Tph1 deficiency, which leads to reduced synthesis of gut-derived serotonin, increased insulin and glucose tolerance compared with normal Tph1 expression. In mice fed a high-fat diet, pharmacological inhibition of Tph1 normalized insulin tolerance and increased glucose tolerance compared with no inhibition. Next steps could include identifying other targets for inhibiting gut-derived serotonin synthesis.

SciBX 5(44); doi:10.1038/scibx.2012.1158
Published online Nov. 8, 2012

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Sumara, G. et al. Cell Metab.; published online Oct. 18, 2012;
Contact: Gerard Karsenty, Columbia University Medical Center, New York, N.Y.