Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Autoimmune disease

Psoriasis

IL-1 receptor-like 2 (IL1RL2; IL-36R)

Mouse studies suggest antagonizing IL-36R could help treat psoriasis. In a mouse model of psoriasis, knocking out Il-36r protected mice from psoriasis symptoms and decreased recruitment of inflammatory macrophages and neutrophils compared with what was seen in wild-type controls. Knocking out the Il-36 receptor antagonist (IL36RN; IL-1F5) led to a more severe disease phenotype. Next steps could include developing IL-36R antagonists.

SciBX 5(43); doi:10.1038/scibx.2012.1131
Published online Nov. 1, 2012

Patent and licensing status unavailable

Tortola, L. et al. J. Clin. Invest.; published online Oct. 15, 2012;
doi:10.1172/JCI63451
Contact: Manfred Kopf, Swiss Federal Institute of Technology Zurich (ETHZ), Zurich, Switzerland
e-mail:
manfred.kopf@ethz.ch