Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Dermatology

Itch

MAS-related GPR member D (MRGPRD)

Human and mouse studies suggest blocking activation of MRGPRD could help treat histamine-independent itch. b-Alanine is known to activate MRGPRD receptors in humans and rodents. In 11 healthy subjects, intradermal injection of the muscle-building supplement b-alanine induced itching. Mrgprd-deficient mice were insensitive to itch induced by b-alanine injection but still showed an itch response to histamine injection. Next steps include developing MRGPRD antagonists and determining whether b-alanine is an endogenous mediator of chronic itch.

SciBX 5(42); doi:10.1038/scibx.2012.1110
Published online Oct. 25, 2012

Work unpatented; licensing status not applicable

Liu, Q. et al. J. Neurosci.; published online Oct. 17, 2012;
doi:10.1523/JNEUROSCI.3509-12.2012
Contact: Xinzhong Dong, The Johns Hopkins University School of Medicine, Baltimore, Md.
e-mail:
xdong2@jhmi.edu
Contact: Robert H. LaMotte, Yale School of Medicine, New Haven, Conn.
e-mail:

robert.lamotte@yale.edu