Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Dermatology

Dermatitis

Leukotriene B4 (LTB4);
leukotriene A4 hydrolase (LTA4H);

Mouse studies suggest inhibiting LTB4 could help treat atopic dermatitis. In a mouse model of atopic dermatitis, knockout of Lta4h or intraperitoneal injection of an inhibitor of the LTB4-synthesizing enzyme LTB4H decreased neutrophil accumulation at dermatitis sites compared with normal Lta4h expression or vehicle injection. In another mouse model of atopic dermatitis, intraperitoneal injection of the LTB4H inhibitor before antigen challenge prevented development of allergic skin inflammation. Next steps include testing topical inhibitors of both LTB4 synthesis and the LTB4 type 1 receptor (BLT1) in an animal model.

SciBX 5(42); doi:10.1038/scibx.2012.1109
Published online Oct. 25, 2012

Patent application filed; available for licensing

Oyoshi, M.K. et al. Immunity; published online Oct. 11, 2012;
doi:10.1016/j.immuni.2012.06.018
Contact: Raif S. Geha, Boston Children's Hospital, Boston, Mass.
e-mail:

raif.geha@childrens.harvard.edu
Contact: Michiko K. Oyoshi, same affiliation as above
e-mail:

michiko.oyoshi@childrens.harvard.edu