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Colorectal cancer

MAP kinase kinase kinase 8 (MAP3K8; COT; TPL2); c-Met proto-oncogene (MET; HGFR); hepatocyte growth factor/scatter factor (HGF/SF)

Mouse studies suggest increasing TPL2 signaling could help prevent colitis-associated cancer. Tpl2-deficient mice showed greater susceptibility to colitis-induced tumor formation and developed higher-grade tumors than nondeficient controls. In mice, inhibiting Hgf/sf-mediated activation of Met prevented the increased susceptibility to tumor formation caused by Tpl2 deficiency. Next steps include studying the mechanism by which TPL2 regulates HGF/SF production in intestinal fibroblasts.

SciBX 5(42); doi:10.1038/scibx.2012.1107
Published online Oct. 25, 2012

Unpatented; mouse model licensed to an undisclosed pharma and available for licensing

Koliaraki, V. et al. J. Clin. Invest.; published online Oct. 15, 2012;
Contact: George Kollias, Alexander Fleming Biomedical Sciences Research Center, Vari, Greece