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Infectious disease

Viral hemorrhagic fever

Bas-Congo virus

Deep sequencing of patient samples suggests the Bas-Congo rhabdovirus could be a diagnostic marker for an acute viral hemorrhagic fever. In a serum sample taken from an acute patient, deep sequencing identified Bas-Congo virus RNA at a concentration of 1.09´106 copies/mL. Serum samples from the patient and an asymptomatic individual that cared for the patient contained high titers of neutralizing antibodies against the virus. Next steps could include screening for molecules that could inhibit replication of Bas-Congo rhabdovirus.

SciBX 5(41); doi:10.1038/scibx.2012.1088
Published online Oct. 18, 2012

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Grard, G. et al. PLoS Pathog.; published online Sept. 27, 2012;
Contact: Eric M. Leroy, International Center of Medical Research of Franceville, Franceville, Gabon

Contact: Charles Y. Chiu, University of California, San Francisco, Calif.