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Cardiovascular disease

Myocardial infarction (MI)

MicroRNA-34a (miR-34a);
miR-34b; miR-34c

Mouse studies suggest locked nucleic acids (LNAs) that inhibit the miR-34 family could promote recovery following MI. In mouse models of MI and cardiac stress, subcutaneous injection of an anti-miR-34 LNA that silenced miR-34a, miR-34b and miR-34c led to less pathological left ventricular cardiac remodeling and cardiac hypertrophy than injection of nontargeting control LNAs. In the models, the anti-miR-34 LNA also increased cardiac function and decreased lung congestion. Next steps include evaluating the anti-miR-34 LNAs in large animal models.

SciBX 5(41); doi:10.1038/scibx.2012.1084
Published online Oct. 18, 2012

Patent and licensing status undisclosed

Bernardo, B.C. et al. Proc. Natl. Acad. Sci. USA; published online Oct. 9, 2012;
Contact: Julie R. McMullen, Baker IDI Heart & Diabetes Institute, Melbourne, Victoria, Australia