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Breast cancer


Mouse studies suggest antagonizing endotrophin could help treat breast cancer. Endotrophin is a cleaved protein derived from collagen type VI a3 (COL6A3). In a mouse model of aggressive mammary adenocarcinoma, endotrophin overexpression in the mammary gland led to increased tumor volume and lung metastases compared with no overexpression. In mice implanted with endotrophin-overexpressing mammary tumors, an antiendotrophin mAb significantly decreased tumor burden compared with IgG control. Next steps include humanizing the antiendotrophin mAb and testing it on human breast and colon cancer samples (see Taking the fat out of cancer, page 1).

SciBX 5(41); doi:10.1038/scibx.2012.1077
Published online Oct. 18, 2012

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Park, J. & Scherer, P.E. J. Clin. Invest.; published online Oct. 8, 2012;
Contact: Philipp E. Scherer, The University of Texas Southwestern Medical Center, Dallas, Texas