Thursday, October 11, 2012
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Alzheimer's disease (AD)
Epidermal growth factor receptor (EGFR)
Drosophila and mouse studies suggest EGFR inhibitors could
help treat AD. In transgenic flies expressing human b-amyloid 42,
the EGFR inhibitors Iressa
prevented memory loss as effectively as the approved AD drug memantine.
In a transgenic mouse model of AD, Iressa decreased memory loss compared with
vehicle. In both a mouse and fly behavioral screen of 2,000 synthetic
compounds that modulate protein kinase activities,
3 compounds prevented memory loss and inhibited b-amyloid
mediated Egfr activity. Next steps include identifying more compounds for
Pharma Inc., Chugai
Pharmaceutical Co. Ltd. and Roche
market Tarceva erlotinib to treat pancreatic cancer
and non-small cell lung cancer (NSCLC).
plc's Iressa is in Phase III testing to treat head and neck
Published online Oct. 11, 2012
Patent application filed;
available for licensing
Wang, L. et al. Proc.
Natl. Acad. Sci. USA; published online Sept. 27, 2012;
Contact: Yi Zhong, Cold Spring Harbor Laboratory, Cold
Spring Harbor, N.Y.
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