Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Cardiovascular disease

Blood clots

Anoctamin 6 (ANO6; TMEM16F)

Mouse and cell culture studies suggest inhibiting TMEM16F could help prevent thrombosis. In mice, knocking out Tmem16f increased bleeding time compared with no knockout and prevented chemical-induced thrombus formation. Studies in human and amphibian cell lines showed that TMEM16F forms a Ca2+-activated, nonselective cation channel needed for lipid scrambling, a process that regulates membrane phospholipid composition, in platelets during coagulation. Next steps could include screening for and evaluating compounds that inhibit TMEM16F.

SciBX 5(40); doi:10.1038/scibx.2012.1050
Published online Oct. 11, 2012

Patent and licensing status unavailable

Yang, H. et al. Cell; published online Sept. 28, 2012;
doi:10.1016/j.cell.2012.07.036
Contact: Lily Yeh Jan, University of California, San Francisco, Calif.
e-mail:
lily.jan@ucsf.edu