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Cardiovascular disease

Blood clots

Anoctamin 6 (ANO6; TMEM16F)

Mouse and cell culture studies suggest inhibiting TMEM16F could help prevent thrombosis. In mice, knocking out Tmem16f increased bleeding time compared with no knockout and prevented chemical-induced thrombus formation. Studies in human and amphibian cell lines showed that TMEM16F forms a Ca2+-activated, nonselective cation channel needed for lipid scrambling, a process that regulates membrane phospholipid composition, in platelets during coagulation. Next steps could include screening for and evaluating compounds that inhibit TMEM16F.

SciBX 5(40); doi:10.1038/scibx.2012.1050
Published online Oct. 11, 2012

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Yang, H. et al. Cell; published online Sept. 28, 2012;
Contact: Lily Yeh Jan, University of California, San Francisco, Calif.