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Musculoskeletal disease

Bone repair

Bone morphogenetic protein 2 (BMP2)

Rat studies identified a benzoic acid-based BMP2 stimulator that could be useful for bone repair. In rats with drill-hole fractures, the BMP2 stimulator increased new bone formation and fracture repair compared with vehicle. Next steps could include evaluating and optimizing the benzoic acid-based molecule in additional models of bone fracture.

SciBX 5(39); doi:10.1038/scibx.2012.1034
Published online Oct. 4, 2012

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Balaramnavar, V.M. et al. J. Med. Chem.; published online Sept. 14, 2012;
Contact: Anil K. Saxena, CSIR-Central Drug Research Institute,
Lucknow, India