Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Infectious disease

Influenza

Mucin 5AC oligomeric mucus/gel-forming (MUC5AC)

Mouse studies suggest increasing MUC5AC levels in the lungs could help protect against influenza infection. In transgenic mice overexpressing Muc5ac, compared with wild-type mice, infection with a mouse-adapted influenza virus decreased lung viral loads. Next steps include determining signal pathways that induce mucin secretion in the lungs and selecting compounds that regulate mucin gene transcription.

SciBX 5(39); doi:10.1038/scibx.2012.1032
Published online Oct. 4, 2012

Model unpatented; unlicensed

Ehre, C. et al. Proc. Natl. Acad. Sci. USA; published online Sept. 24, 2012;
doi:10.1073/pnas.1206552109
Contact: Camille Ehre, The University of North Carolina at Chapel Hill, Chapel Hill, N.C.
e-mail:

cehre@med.unc.edu