Indication

Target/marker/pathway

Summary

Licensing status

Publication and contact information

Endocrine/metabolic disease

Obesity

PTEN (MMAC1; TEP1)

Human studies suggest PTEN mutations could help predict obesity risk. Twenty-one nondiabetic individuals with loss-of-function PTEN mutations had greater insulin sensitivity and BMIs than healthy subjects with wild-type PTEN. A meta-analysis of published genomics data from healthy individuals identified associations between PTEN SNPs and high plasma levels of fasting insulin and low levels of fasting glucose. Ongoing work includes investigating the mechanisms by which insulin sensitivity contributes to obesity in individuals harboring PTEN mutations.

SciBX 5(38); doi:10.1038/scibx.2012.1005
Published online Sept. 27, 2012

Unpatented; available for partnering

Pal, A. et al. N. Engl. J. Med.; published online Sept. 13, 2012;
doi:10.1056/NEJMoa1113966
Contact: Anna L. Gloyn, University of Oxford, Oxford, U.K.
e-mail:
anna.gloyn@drl.ox.ac.uk