Thursday, September 27, 2012
Publication and contact
Acute myeloid leukemia
FMS-like tyrosine kinase 3 (FLT3;
In vitro and mouse studies suggest statins
could help treat FLT3-mutant AML. In mouse bone marrow cells
expressing mutant Flt3, Lescol
prevented Flt3 glycosylation and cell surface translocation, which is
required for FLT3-driven oncogenesis, and decreased proliferation compared
with no treatment. In mice, fluvastatin decreased engraftment of mutant Flt3-expressing
bone marrow cells and increased survival compared with saline. Next steps
could include evaluating statins in combination with FLT3 inhibitors in mouse
models of Flt3-driven AML.
AG markets Lescol, an HMG-CoA
reductase inhibitor, to treat hypercholesterolemia and
prevent cardiovascular disease.
At least 10 companies have FLT3 inhibitors in clinical and preclinical
testing to treat various cancers.
Published online Sept. 27, 2012
Patent and licensing status
Williams, A.B. et al.
Blood; published online Aug. 27, 2012;
Contact: Donald Small, The Johns Hopkins University School
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]