Thursday, September 27, 2012
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Acute myeloid leukemia
FMS-like tyrosine kinase 3 (FLT3;
In vitro and mouse studies suggest statins
could help treat FLT3-mutant AML. In mouse bone marrow cells
expressing mutant Flt3, Lescol
prevented Flt3 glycosylation and cell surface translocation, which is
required for FLT3-driven oncogenesis, and decreased proliferation compared
with no treatment. In mice, fluvastatin decreased engraftment of mutant Flt3-expressing
bone marrow cells and increased survival compared with saline. Next steps
could include evaluating statins in combination with FLT3 inhibitors in mouse
models of Flt3-driven AML.
AG markets Lescol, an HMG-CoA
reductase inhibitor, to treat hypercholesterolemia and
prevent cardiovascular disease.
At least 10 companies have FLT3 inhibitors in clinical and preclinical
testing to treat various cancers.
Published online Sept. 27, 2012
Patent and licensing status
Williams, A.B. et al.
Blood; published online Aug. 27, 2012;
Contact: Donald Small, The Johns Hopkins University School
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